Sodium channel NaV1.9 mutations associated with insensitivity to pain dampen neuronal excitability
نویسندگان
چکیده
منابع مشابه
Sodium channel NaV1.9 mutations associated with insensitivity to pain dampen neuronal excitability.
Voltage-gated sodium channel (NaV) mutations cause genetic pain disorders that range from severe paroxysmal pain to a congenital inability to sense pain. Previous studies on NaV1.7 and NaV1.8 established clear relationships between perturbations in channel function and divergent clinical phenotypes. By contrast, studies of NaV1.9 mutations have not revealed a clear relationship of channel dysfu...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2017
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci92373